The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Fibroblast growth factor (FGF) signaling controls fundamental processes such as
proliferation, differentiation and migration throughout mammalian development. Here we …

Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell
fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem …

Fibroblast growth factor (FGF) signalling has been implicated during several phases of early
embryogenesis, including the patterning of the embryonic axes, the induction and/or …

Human artificial chromosome (HAC) has several advantages as a gene therapy vector,
including stable episomal maintenance that avoids insertional mutations and the ability to …

Reprogramming of somatic cells into pluripotent stem cells has been reported by introducing
a combination of several transcription factors (Oct3/4, Sox2, Klf4 and c-Myc). The induced …

Background Although the rat is extensively used as a laboratory model, the inability to utilize
germ line-competent rat embryonic stem (ES) cells has been a major drawback for studies …

Murine pluripotent stem cells can exist in two functionally distinct states, LIF-dependent
embryonic stem cells (ESCs) and bFGF-dependent epiblast stem cells (EpiSCs). However …

Human induced pluripotent stem (iPS) cells have the potential to establish a new field of
promising regenerative medicine. Therefore, the safety and the efficiency of iPS-derived …

Recent breakthroughs in stem cell biology, especially the development of induced
pluripotent stem cell technique, have generated tremendous enthusiasm and efforts to …