Expression of prostate‐specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non …

V Yao, CE Berkman, JK Choi, DS O'Keefe… - The …, 2010 - Wiley Online Library
BACKGROUND Prostate specific membrane antigen (PSMA) is a unique folate hydrolase
that is significantly upregulated in prostate cancer. In a mouse model, PSMA is able to …

The choice of the antigen in the dendritic cell-based vaccine therapy for prostate cancer

L Matera - Cancer treatment reviews, 2010 - Elsevier
Tumor antigens (TA) are promising candidates for targeted treatment of prostate cancer
(PCa). Critical issues in the preparation of dendritic cell (DC)-based TA vaccines are the DC …

Bioisosterism of urea-based GCPII inhibitors: synthesis and structure–activity relationship studies

H Wang, Y Byun, C Barinka, M Pullambhatla… - Bioorganic & medicinal …, 2010 - Elsevier
We report a strategy based on bioisosterism to improve the physicochemical properties of
existing hydrophilic, urea-based GCPII inhibitors. Comprehensive structure–activity …

Differential gene expression in benign prostate epithelium of men with and without prostate cancer: evidence for a prostate cancer field effect

MC Risk, BS Knudsen, I Coleman, RF Dumpit… - Clinical Cancer …, 2010 - AACR
Background: Several malignancies are known to exhibit a “field effect,” whereby regions
beyond tumor boundaries harbor histologic or molecular changes that are associated with …

Η μοριακή σταδιοποίηση με multiplex PCR του καρκίνου του προστάτη

Ζ Παντελεάκου - 2010 - didaktorika.gr
Η διασπορά της νεοπλασματικής νόσου είναι η κύρια αιτία θανάτου από καρκίνο στους
ασθενείς με καρκίνο προστάτη. Νεότερες αποδείξεις συνηγορούν ότι τα καρκινικά κύτταρα …

Klonování, exprese a biochemická charakterizace myší glutamátkarboxypeptidasy II

T Knedlík - 2010 - dspace.cuni.cz
Glutamátkarboxypeptidasa II (GCPII) je membránová metalopeptidasa, jež je u člověka
exprimována v mnoha tkáních, zejména pak v prostatě, centrální nervové soustavě a tenkém …