Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

Changes to the chromatin structure accompany aging, but the molecular mechanisms
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …

The paradigm sirtuin, Sir2p, of budding yeast is required for establishing cellular age
asymmetry, which includes the retention of damaged and aggregated proteins in mother …

Sirtuins comprise a family of NAD+-dependent protein deacetylases and ADP-
ribosyltransferases. Mammalian SIRT1–a homolog of yeast Sir2, the prototypical member of …

The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …

Yeast Sir2 deacetylase is a component of the silent information regulator (SIR) complex
encompassing Sir2/Sir3/Sir4. Sir2 is recruited to telomeres through Rap1, and this complex …

Genomes are organized into complex higher-order structures by folding of the DNA into
chromatin fibers, chromosome domains, and ultimately chromosomes. The higher-order …

Human life expectancy in developed countries has increased steadily for over 150 years,
through improvements in public health and lifestyle. More people are hence living long …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …