Research on depression and antidepressant drugs is necessary, as many patients display
poor response to therapy. Different symptomatic and pathophysiological features have been …

In traditional Oriental medicine, some herbal combinations that include Bupleurum falcatum
(BFM) as a major ingredient are known to effectively treat depressive-like disorders. In the …

Serotonin (5-HT) exerts pleiotropic effects in the human cardiovascular system. Some of the
effects are thought to be mediated via 5-HT4 receptors, which are expressed in the human …

Our earlier studies have demonstrated that the non-selective group III mGlu receptor agonist,
ACPT-I, produced anxiolytic rather than antidepressant-like actions after its peripheral …

Rationale Several studies have suggested that modulation of the glutamatergic system
could be a new, efficient way to achieve antidepressant activity. Behavioral data showed that …

Background and purpose: Despite decreased presynaptic 5‐HT1A and altered 5‐HT2A
receptor function in genetically‐deficient serotonin (5‐HT) transporter (SERT) mice, the 5 …

The involvement of the noradrenergic system, imidazoline, dopaminergic and adenosinergic
receptors in the antidepressant-like action of tramadol in the mouse forced swimming test …

Behavioral studies show that modulation of the glutamatergic system might be an efficient
way to achieve antidepressant activity. Among the group III metabotropic glutamate (mGlu) …

A substantial body of research has developed concerning the role of serotonin (5-HT) in the
etiology and treatment of major depressive disorder (MDD). The first section of this chapter …

Melatonin and its immediate precursor, N‐acetylserotonin (NAS), exert antidepressant
effects in experimental models and clinical studies. We reported that melatonin and NAS …