Intellectual disability (ID) is the leading socio-economic problem of health care, but
compared to autism and schizophrenia, it has received very little public attention. Important …

We used data from studies of copy-number variants (CNVs), single-gene associations,
growth-signaling pathways, and intermediate phenotypes associated with brain growth to …

Background Large, rare chromosomal deletions and duplications known as copy number
variants (CNVs) have been implicated in neurodevelopmental disorders similar to attention …

Autism spectrum disorders (ASD) and schizophrenia are neurodevelopmental disorders for
which recent evidence indicates an important etiologic role for rare copy number variants …

The duplication architecture of the human genome predisposes our species to recurrent
copy number variation and disease. Emerging data suggest that this mechanism of mutation …

The discovery of 'high-risk'de novo copy number variants (CNVs) associated with
neuropsychiatric disorders such as schizophrenia offers the opportunity to translate these …

Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a
variety of human diseases, especially in cancer. Here, we provide an account of newly …

The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …

The idea that schizophrenia has its origins in early development dates back at least to the
modern classification of the syndrome by Emil Kraepelin and Eugen Bleuler, both of whom …

Recent developments in microarray technology have revealed the presence of many
submicroscopic deletions and duplications in the human genome. Some of these have been …