A number of drugs have been withdrawn from the market or severely restricted in their use
because of unexpected toxicities that become apparent only after the launch of new drug …

Drugs are generally converted to biologically inactive forms and eliminated from the body,
principally by hepatic metabolism. However, certain drugs undergo biotransformation to …

A 2-aminothiazole derivative 1 was developed as a potential inhibitor of the oncology target
AKT, a serine/threonine kinase. When incubated in rat and human liver microsomes in the …

A large body of circumstantial evidence suggests that metabolic activation of drug
candidates to chemically reactive electrophilic metabolites that are capable of covalently …

The metabolism, pharmacokinetics, and excretion of a potent and selective 5-
hydroxytryptamine1B receptor antagonist elzasonan have been studied in six healthy male …

Drug discovery is an extremely challenging, convoluted, and expensive process, which
demands a very close knit interaction of a variety of multidisciplinary teams. Success of such …

Oxidative metabolism mediated by the group of hepatic enzymes known as the cytochrome
P450 represents a significant clearance pathway for many drugs prescribed today. Given the …

Two major reasons for drug attrition today are preclinical toxicity and human adverse events
(Kola and Landis, 2004; Guengerich and MacDonald, 2007). Therefore, it is imperative to be …