Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …

Case-parent trios were used in a genome-wide association study of cleft lip with and without
cleft palate. SNPs near two genes not previously associated with cleft lip with and without …

Excessive alcohol consumption is one of the leading causes of preventable death in the
United States. Approximately 14% of those who use alcohol meet criteria during their lifetime …

Dental caries is influenced by a complex interplay of genetic and environmental factors,
including dietary habits. Previous reports have characterized the influence of genetic …

This study is a retrospective, case control study involving 535 preterm infants examining the
roles of sequence polymorphisms in genes that mediate host immune responses to bacterial …

Congenital Toxoplasma gondii infection can result in intracranial calcification,
hydrocephalus and retinochoroiditis. Acquired infection is commonly associated with ocular …

Background Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major
cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C …

Although multiple genes have been identified as genetic risk factors for isolated, non-
syndromic cleft lip with/without cleft palate (CL/P), a complex and heterogeneous birth …

Cardiac abnormalities are one of the most common congenital defects observed in
individuals with Down syndrome. Considerable research has implicated both folate …

Variability in the age of onset and number of tumors is occasionally described among
retinoblastoma patients, and possible genetic modifiers might lie in the pRB or p53 …