Abstract In 2009, the American Cancer Society (ACS) Prostate Cancer Advisory Committee
began the process of a complete update of recommendations for early prostate cancer …

Background Cabazitaxel is a novel tubulin-binding taxane drug with antitumour activity in
docetaxel-resistant cancers. We aimed to compare the efficacy and safety of cabazitaxel …

Background Prostate cancer is one of the leading causes of death from malignant disease
among men in the developed world. One strategy to decrease the risk of death from this …

BACKGROUND: Screening for prostate cancer (PC) is controversial due to uncertainties
about its efficiency. OBJECTIVE: We aimed to develop strategies to reduce the number of …

Active surveillance is a solution to the widely acknowledged problem of overdiagnosis and
overtreatment of clinically insignificant disease which accompanies early detection of …

Background Recently, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer
Screening Trial published 7-year complete prostate cancer mortality results, which showed …

OBJECTIVE: To compare DNA damage in ejaculated and testicular spermatozoa in patients
with previously unsuccessful oral antioxidant treatment. DESIGN: Prospective clinical study …

In 2009, two important papers resulting from large, cooperative, randomised, controlled trials
[1, 2] have appeared addressing the issue of screening for prostate cancer (PCa). Both …

Screening for prostate cancer using prostate-specific antigen (PSA) has been appealing.
However, the significant associated decline in prostate cancer mortality comes at the cost of …

BACKGROUND: To estimate the benefits of prostate-specific antigen (PSA) screening on
prostate cancer (Pca) metastasis and Pca-specific mortality, we compared two populations …