Early studies on plant polyamine research pointed to their involvement in responses to
different environmental stresses. During the last few years, genetic, transcriptomic and …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …

The p53 tumor suppressor protein has well-established roles in monitoring various types of
stress signals by activating specific transcriptional targets that control cell cycle arrest and …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

Histone modifications serve as regulatory marks that are instrumental for the control of
transcription and chromatin architecture. Strict regulation of gene expression patterns is …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …

The tumor suppressor p53 is regulated by numerous post-translational modifications. Lysine
methylation has recently emerged as a key post-translational modification that alters the …

Histone-modifying enzymes can regulate DNA damage-induced apoptosis through
modulation of p53 function. Here, we show that, in p53-deficient tumor cells, Set9 and LSD1 …

Following its tyrosine phosphorylation, STAT3 is methylated on K140 by the histone methyl
transferase SET9 and demethylated by LSD1 when it is bound to a subset of the promoters …

NF-κB, a central coordinator of immune and inflammatory responses, must be tightly
regulated. We describe a NF-κB regulatory pathway that is driven by reversible lysine …