Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …
systems biology with information provided by data-driven prediction methods. To this end …
Agent-based modeling of endotoxin-induced acute inflammatory response in human blood leukocytes
X Dong, PT Foteinou, SE Calvano, SF Lowry… - PloS one, 2010 - journals.plos.org
Background Inflammation is a highly complex biological response evoked by many stimuli. A
persistent challenge in modeling this dynamic process has been the (nonlinear) nature of …
persistent challenge in modeling this dynamic process has been the (nonlinear) nature of …
Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms
S Christley, B Lee, X Dai, Q Nie - BMC systems biology, 2010 - Springer
Background Simulation of sophisticated biological models requires considerable
computational power. These models typically integrate together numerous biological …
computational power. These models typically integrate together numerous biological …
Multiscale model for the assessment of autonomic dysfunction in human endotoxemia
PT Foteinou, SE Calvano, SF Lowry… - Physiological …, 2010 - journals.physiology.org
Severe injury and infection are associated with autonomic dysfunction. The realization that a
dysregulation in autonomic function may predispose a host to excessive inflammatory …
dysregulation in autonomic function may predispose a host to excessive inflammatory …
Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation
Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in
inflammatory diseases. The two subsets are thought to counter-regulate each other, and …
inflammatory diseases. The two subsets are thought to counter-regulate each other, and …
Gradient descent optimization in gene regulatory pathways
Background Gene Regulatory Networks (GRNs) have become a major focus of interest in
recent years. Elucidating the architecture and dynamics of large scale gene regulatory …
recent years. Elucidating the architecture and dynamics of large scale gene regulatory …
Altered signaling through IL-12 receptor in children with very high serum IgE levels
A Fusco, I Vigliano, L Palamaro, E Cirillo, G Aloj… - Cellular …, 2010 - Elsevier
An alteration of Th1/Th2 homeostasis may lead to diseases in humans. In this study, we
investigated whether an impaired IL-12R signaling occurred in children with elevated serum …
investigated whether an impaired IL-12R signaling occurred in children with elevated serum …
[PDF][PDF] A description of the manual curation of the nodes and interactions underlying the network model
ITK activates PLCPG - researchgate.net
From a general perspective the curation process was guided by recent reviews and original
articles relating to Th1/Th2 cell differentiation in vitro and in vivo [1-3] and its transcriptional …
articles relating to Th1/Th2 cell differentiation in vitro and in vivo [1-3] and its transcriptional …
[PDF][PDF] ALL RIGHTS RESERVED
PT Foteinou - 2010 - researchgate.net
©2010 Panagiota T. Foteinou ALL RIGHTS RESERVED Page 1 ©2010 Panagiota T. Foteinou
ALL RIGHTS RESERVED Page 2 A MULTISCALE MODEL FOR THE ASSESSMENT OF …
ALL RIGHTS RESERVED Page 2 A MULTISCALE MODEL FOR THE ASSESSMENT OF …
[PDF][PDF] Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding
We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …
systems biology with information provided by data-driven prediction methods. To this end …