Background: Glia are traditionally known as support cells for neurons, and their role in
neurodegeneration has been largely considered secondary to neuronal dysfunction. We …

Abstract Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system
atrophy (MSA) are adult onset neurodegenerative disorders characterised by prominent …

Parkinson's disease, an age-related neurodegenerative disorder, is characterized by the
loss of dopamine neurons in the substantia nigra, the accumulation of α-synuclein in Lewy …

Background Activated microglia are a feature of the host response to neurodegeneration in
Parkinson's disease (PD) and are thought to contribute to disease progression. Recent …

Background Increased reactive microglia are a histological characteristic of Parkinson's
disease (PD) brains, positively correlating with levels of deposited α-synuclein protein. This …

Animal models with high predictive power are a prerequisite for translational research. The
closer the similarity of a model to Parkinson's disease (PD), the higher is the predictive value …

Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by
a progressive and specific loss of certain brain cell populations. Current therapeutic …

Activation of microglia and inflammation-mediated neurotoxicity are suggested to have key
roles in the pathogenesis of several neurodegenerative disorders. We recently published an …

Parkinson disease (PD) is the most common movement disorder. It is characterized by
bradykinesia, postural instability, resting tremor, and rigidity associated with the progressive …

Parkinson disease (PD) is a relatively common neurodegenerative disorder characterized
by the progressive degeneration of dopaminergic neurons in the substantia nigra. About 5 …