Sirtuins, aging, and medicine
L Guarente - New England Journal of Medicine, 2011 - Mass Medical Soc
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What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
Background Resveratrol is a natural compound suggested to have beneficial health effects.
However, people are consuming resveratrol for this reason without having the adequate …
However, people are consuming resveratrol for this reason without having the adequate …
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a
number of enzymes and transcriptional regulators. The fact that NAD+ levels control SIRT1 …
number of enzymes and transcriptional regulators. The fact that NAD+ levels control SIRT1 …
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
C Burnett, S Valentini, F Cabreiro, M Goss… - nature, 2011 - nature.com
Overexpression of sirtuins (NAD+-dependent protein deacetylases) has been reported to
increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans …
increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans …
Sirtuins at a glance
T Nakagawa, L Guarente - Journal of cell science, 2011 - journals.biologists.com
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
M Kitada, S Kume, N Imaizumi, D Koya - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Despite the beneficial effects of resveratrol (RSV) on cardiovascular disease
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
Modulation of endogenous antioxidant system by wine polyphenols in human disease
Numerous studies indicate that moderate red wine consumption is associated with a
protective effect against all-cause mortality. Since oxidative stress constitutes a unifying …
protective effect against all-cause mortality. Since oxidative stress constitutes a unifying …
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
Notch signalling is a key intercellular communication mechanism that is essential for cell
specification and tissue patterning, and which coordinates critical steps of blood vessel …
specification and tissue patterning, and which coordinates critical steps of blood vessel …
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
Signaling through the kinase Akt regulates many biological functions. Akt is activated during
growth factor stimulation through a process that requires binding of Akt to …
growth factor stimulation through a process that requires binding of Akt to …
Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
PC Tseng, SM Hou, RJ Chen, HW Peng… - Journal of Bone and …, 2011 - academic.oup.com
Reports of the bone‐protective effects of resveratrol, a naturally occurring phytoestrogen and
agonist for the longevity gene SIRT1, have highlighted this compound as a candidate for …
agonist for the longevity gene SIRT1, have highlighted this compound as a candidate for …