Genetic polymorphisms in drug-metabolizing enzymes are frequently responsible for high
variability in the pharmacokinetics of certain drugs leading to large variations in drug efficacy …

Introduction: Triazole antifungal agents are often prescribed as first-line therapy for
candidemia, in non-neutropenic hosts and invasive pulmonary aspergillosis, and in critically …

Purpose Voriconazole is widely used to treat invasive aspergillosis after lung
transplantation. In cystic fibrosis patients, the interindividual variability in drug disposition …

In clinical practice, antifungal therapy may be switched from fluconazole to voriconazole;
such sequential use poses the potential for drug interaction due to cytochrome P450 2C19 …

Antifungal prophylaxis in hematopoietic stem cell transplant recipients is a rapidly evolving
field. For this prophylaxis to be beneficial and cost-effective, the risk of a life-threatening …

目的系统评价CYP2C19 基因多态性与伏立康唑药物代谢动力学的关系. 方法至2011 年2 月,
计算机检索Cochrane 图书馆, PubMed, Embase, Med-line, CNKI 等数据库 …

Pharmacogenetic polymorphisms that change the amino acid sequences in coding regions
only account for part of the interindividual differences in disease susceptibility and drug …

We read with interest the article by Li-Wan-Po and colleagues on the functional and clinical
implications of the recently discovered CYP2C19* 17 variant allele [1]. The authors examine …

By attending to factors altering pharmacokinetics, blood levels of the respective triazoles can
be optimized for efficacy and safety. Under certain circumstances, therapeutic drug …

" 伏立康唑" 目前被认为是治疗侵袭性真菌感染应用较多的抗真菌药物, 但由于其具有潜在的较多
的药物相互作用及药代动力学个体间差异较大, 使其在临床使用过程中问题重重. 1 例54 a …