Atopic dermatitis and psoriasis are 2 of the most common inflammatory skin diseases. They
are similar in that they are complex inherited diseases involving genes that encode immune …

Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines,
alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced …

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the
spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent …

Genome-wide association studies (GWAS) have defined over 150 genomic regions
unequivocally containing variation predisposing to immune-mediated disease. Inferring …

Atopic dermatitis is a chronic, relapsing form of inflammatory skin disorder that is affected by
genetic and environmental factors. We performed a genome-wide association study of …

Development of a suitable mouse model would facilitate the investigation of
pathomechanisms underlying human psoriasis and would also assist in development of …

We performed a genome-wide association study with 706 individuals with leprosy and 5,581
control individuals and replicated the top 24 SNPs in three independent replication samples …

Narrow-band ultraviolet-B (NB-UVB) phototherapy is an effective treatment for psoriasis. The
molecular mechanisms underlying its efficacy are incompletely understood. To identify NB …

Modern technological innovations have advanced our understanding of the genetic basis of
spondyloarthritis. In ankylosing spondylitis (AS), where the major histocompatibility complex …

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control
subjects was performed to investigate the contribution of the deletion of genes LCE3C and …