Characterized by a combination of abnormalities in language, social cognition and mental
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly …

Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of
mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have …

Background With the fast advances in nextgen sequencing technology, high-throughput
RNA sequencing has emerged as a powerful and cost-effective way for transcriptome study …

Cytosine methylation is the major epigenetic modification of metazoan DNA. Although there
is strong evidence that active DNA demethylation occurs in animal cells, the molecular …

Recent advances in the genetics of autism spectrum disorders (ASDs) are offering new
valuable insights into molecular and cellular mechanisms of pathology. At the same time, the …

Mental retardation (MR) and autism are highly heterogeneous neurodevelopmental
disorders. IL-1-receptor accessory protein-like 1 (IL1RAPL1) is responsible for …

Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in
the CNS remains largely unknown. To identify the pathways downstream of GRN, we used …

We review the contributions and limitations of genome-wide array-based identification of
copy number variants (CNVs) in the clinical diagnostic evaluation of patients with mental …

Autism spectrum disorder (ASD) is a severe neuropsychiatric disorder which has complex
pathobiology with profound influences of genetic factors in its development. Although the …

The Autism Spectrum Disorders (ASD) represent a clinically heterogeneous set of conditions
with strong hereditary components. Despite substantial efforts to uncover the genetic basis …