Pharmacogenetics of response to antipsychotics in patients with schizophrenia
This review presents the findings of pharmacogenetic studies exploring the influence of
gene variants on antipsychotic treatment response, in terms of both symptom improvement …
gene variants on antipsychotic treatment response, in terms of both symptom improvement …
Toward understanding genetic risk for differential antipsychotic response in individuals with schizophrenia
MJ Arranz, JC Munro - Expert Review of Clinical Pharmacology, 2011 - Taylor & Francis
Antipsychotic treatment response is highly heterogeneous and unpredictable in terms of
both efficacy and side effects. A combination of factors influences treatment outcome …
both efficacy and side effects. A combination of factors influences treatment outcome …
Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine
OBJECTIVE: This study aims to improve understanding of antipsychotic non/response and
assess the potential for personalized schizophrenia treatment. METHODS: We used data …
assess the potential for personalized schizophrenia treatment. METHODS: We used data …
Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics
H Visscher, U Amstutz, J Sistonen… - Journal of …, 2011 - journals.lww.com
Individual response to medication is highly variable. For many drugs, a substantial
proportion of patients show suboptimal response at standard doses, whereas others …
proportion of patients show suboptimal response at standard doses, whereas others …
Systematic review of the Genomewide Association Studies (GWAS) in schizophrenia
A Valiente, A Lafuente, M Bernardo - Revista de Psiquiatría y Salud Mental …, 2011 - Elsevier
Introduction Heritability in schizophrenia can reach up to 80% and the risk in families is 5–10
times higher than in the general population. The large contribution of genetics in this …
times higher than in the general population. The large contribution of genetics in this …
Statistical issues and approaches in endophenotype research
The endophenotype concept was initially proposed to enhance the power of genetic studies
of complex disorders. It is closely related to the genetic component in a liability-threshold …
of complex disorders. It is closely related to the genetic component in a liability-threshold …
Revisión sistemática de los Genomewide Association Studies (GWAS) en esquizofrenia
A Valiente, A Lafuente, M Bernardo - Revista de Psiquiatría y Salud Mental, 2011 - Elsevier
Introducción La heredabilidad en la esquizofrenia llega hasta el 80% y el riesgo en
familiares es 5-10 veces mayor que en la población general. La gran contribución genética …
familiares es 5-10 veces mayor que en la población general. La gran contribución genética …
[引用][C] Strategies, strengths and limitations in pharmacogenetic studies of antipsychotics
A Lafuente - Revista de psiquiatria y salud mental (English Edition), 2011 - infona.pl
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[引用][C] Estrategias, fortalezas y limitaciones en estudios de Farmacogenética con antipsicóticos
A Lafuente - Revista de psiquiatría y salud mental, 2011 - dialnet.unirioja.es