This review presents the findings of pharmacogenetic studies exploring the influence of
gene variants on antipsychotic treatment response, in terms of both symptom improvement …

Antipsychotics are the cornerstone of treatment for psychotic and some nonpsychotic
disorders. However, despite pharmacologic advances, considerable areas of need remain …

Background Several lines of evidence have implicated the pro-inflammatory cytokine
interleukin-1beta (IL-1β) in the etiology of schizophrenia. Although a number of genetic …

Pharmacogenomic investigation from both genome-wide association studies and
experiments focused on candidate loci involved in drug mechanism and metabolism has …

Objective diagnostic tools are required for neuropsychiatric disorders. Gene expression in
blood cells may provide such a tool and has already been used to construct classifiers …

OBJECTIVE: This study aims to improve understanding of antipsychotic non/response and
assess the potential for personalized schizophrenia treatment. METHODS: We used data …

Antipsychotic treatment response is highly heterogeneous and unpredictable in terms of
both efficacy and side effects. A combination of factors influences treatment outcome …

Research in the area of pharmacogenetics in psychiatry is aimed at identifying clinically
relevant genetic variations that can predict treatment response. Ultimately, the goal is to …

In pharmacogenomics studies, the analysis of gene-gene interactions increasingly plays a
crucial role in characterizing a phenotypic trait that involves complex pharmacological …

Introduction Heritability in schizophrenia can reach up to 80% and the risk in families is 5–10
times higher than in the general population. The large contribution of genetics in this …