Do PPAR‐Gamma Agonists Have a Future in Parkinson′ s Disease Therapy?

AR Carta, A Pisanu, E Carboni - Parkinson's disease, 2011 - Wiley Online Library
Thiazolidinediones (TZDs) are peroxisome proliferator‐activated receptor (PPAR)‐γ
agonists commonly used as insulin‐sensitizing drugs for the treatment of type 2 diabetes. In …

Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury

E Esposito, S Cuzzocrea - Expert opinion on therapeutic targets, 2011 - Taylor & Francis
Introduction: Traumatic spinal cord injury (SCI) causes severe and permanent functional
deficits, due to the primary mechanical insult, followed by secondary tissue degeneration …

Antidepressant-like effect of pioglitazone in the forced swimming test in mice: the role of PPAR-gamma receptor and nitric oxide pathway

MS Sadaghiani, M Javadi-Paydar… - Behavioural brain …, 2011 - Elsevier
In this study, the potential antidepressant-like effects of pioglitazone and the possible
involvement of peroxisome proliferator-activated receptor gamma (PPARγ) and nitric oxide …

[HTML][HTML] Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor-alpha and-gamma: implications for PPARs' roles in renal function

F Cabezas, J Lagos, C Céspedes, CP Vio… - PloS one, 2011 - journals.plos.org
Background Megalin is a large endocytic receptor with relevant functions during
development and adult life. It is expressed at the apical surface of several epithelial cell …

Signal transduction pathways involved in PPARβ/δ‐induced neuronal differentiation

B D'Angelo, E Benedetti, S Di Loreto… - Journal of cellular …, 2011 - Wiley Online Library
Neuroblastomas are pediatric tumors originating from neuroblasts in the developing
peripheral nervous system. The neurotrophin brain‐derived neurotrophic factor (BDNF) is a …

Fenofibrate increases neuronal vasoconstrictor response in mesenteric arteries from diabetic rats: role of noradrenaline, neuronal nitric oxide and calcitonin gene …

L del Campo, J Blanco-Rivero, G Balfagon - European journal of …, 2011 - Elsevier
We evaluated the possible effects of long-term fenofibrate treatment on adrenergic, nitrergic
and CGRP-ergic innervation function in mesenteric arteries from streptotozin-induced …

Role of different types of potassium channels and peroxisome proliferator-activated receptors γ in the antidepressant-like activity of bis selenide in the mouse tail …

CR Jesse, EA Wilhelm, CF Bortolatto, CW Nogueira - Neuroscience letters, 2011 - Elsevier
In the present study we investigated the role of potassium (K+) channels and peroxisome
proliferator-activated receptor gamma (PPARγ) in the antidepressant-like effect of bis …

Cannabinoids as potential new therapeutics of gastrointestinal motility and inflammatory disorders

L Roberts - 2011 - orca.cardiff.ac.uk
Cannabinoids show potential as new treatments for inflammatory bowel disease (IBD),
exerting several favourable effects in the gut, including anti-inflammatory and …

Fenofibrate increases neuronal vasoconstrictor response in mesenteric arteries from diabetic rats: Role of noradrenaline, neuronal nitric oxide and calcitonin gene …

L Del Campo Milán, J Blanco-Rivero, G Balfagón - 2011 - docta.ucm.es
Fenofibrate increases neuronal vasoconstrictor response in mesenteric arteries from diabetic
rats: Role of noradrenaline, neuron Page 1 Cardiovascular Pharmacology Fenofibrate …

The role of Peroxisome Proliferator Activated Receptors in Amyotrophic Lateral Sclerosis: potential mechanisms for neuroprotection

V Benedusi - 2011 - air.unimi.it
The vast majority of neurodegenerative disorders are adult-onset, incurable diseases.
Understanding the pathogenetic mechanisms underlying these disorders and finding …