Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date,
aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

Advanced age is the main risk factor for most chronic diseases and functional deficits in
humans, but the fundamental mechanisms that drive ageing remain largely unknown …

Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome
missegregation events in aneuploid cells promote chromosomal instability (CIN) that may …

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that
cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer …

The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that
affect both cancer and development. It is now emerging that these proteins also regulate …

High expression of the protein kinase Bub1 has been observed in a variety of human tumors
and often correlates with poor clinical prognosis, but its molecular and cellular …

Expression of the c-Myc oncoprotein is affected by conserved threonine 58 (T58) and serine
62 (S62) phosphorylation sites that help to regulate c-Myc protein stability, and altered ratios …

Most human cancers are aneuploid and have chromosomal instability, which contrasts to the
inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human …

Mice are an ideal mammalian model for studying the genetics of aging: considerable
resources are available, the generation time is short, and the environment can be easily …