Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

Environmental chemicals have significant impacts on biological systems. Chemical
exposures during early stages of development can disrupt normal patterns of development …

The tarsal glands of Meibom (glandulae tarsales) are large sebaceous glands located in the
eyelids and, unlike those of the skin, are unassociated with hairs. According to Duke-Elder …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …

Mesenchymal stromal cells (MSCs) can be isolated from various tissues such as bone
marrow aspirates, fat or umbilical cord blood. These cells have the ability to proliferate in …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

Adipogenesis is tightly controlled by a complex network of transcription factors acting at
different stages of differentiation. Peroxisome proliferator‐activated receptor γ (PPARγ) and …

Obesity and related disorders are a burgeoning public health epidemic, particularly in the
US Currently 34% of the US population is clinically obese (BMI> 30) and 68% are …

Inulin-type fructans (ITF) are nondigestible/fermentable carbohydrates which are able—
through the modification of the gut microbiota—to counteract high-fat (HF) diet-induced …