Cancer epigenetics reaches mainstream oncology
M Rodríguez-Paredes, M Esteller - Nature medicine, 2011 - nature.com
Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …
The redox basis of epigenetic modifications: from mechanisms to functional consequences
Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of
metabolism, stress resistance and longevity. Apart from its role as an important redox carrier …
metabolism, stress resistance and longevity. Apart from its role as an important redox carrier …
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a
number of enzymes and transcriptional regulators. The fact that NAD+ levels control SIRT1 …
number of enzymes and transcriptional regulators. The fact that NAD+ levels control SIRT1 …
Imaging cytosolic NADH-NAD+ redox state with a genetically encoded fluorescent biosensor
NADH is a key metabolic cofactor whose sensitive and specific detection in the cytosol of
live cells has been difficult. We constructed a fluorescent biosensor of the cytosolic NADH …
live cells has been difficult. We constructed a fluorescent biosensor of the cytosolic NADH …
Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic …
Y Kawai, LK Garduno, M Theodore, J Yang… - Journal of Biological …, 2011 - ASBMB
Activation of Nrf2 by covalent modifications that release it from its inhibitor protein Keap1 has
been extensively documented. In contrast, covalent modifications that may regulate its action …
been extensively documented. In contrast, covalent modifications that may regulate its action …
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response
B Wang, MK Hasan, E Alvarado, H Yuan, H Wu… - Oncogene, 2011 - nature.com
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in regenerating
nicotinamide adenine dinucleotide (NAD+) from nicotinamide in mammals. NAMPT has …
nicotinamide adenine dinucleotide (NAD+) from nicotinamide in mammals. NAMPT has …
Protective effects and mechanisms of sirtuins in the nervous system
Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone
deacetylases whose activities are dependent on and regulated by nicotinamide adenine …
deacetylases whose activities are dependent on and regulated by nicotinamide adenine …
Protective roles of SIRT1 in atherosclerosis
S Stein, CM Matter - Cell cycle, 2011 - Taylor & Francis
SIRT1 is a NAD+-dependent class III histone deacetylase (HDAC) that mediates the effects
of caloric restriction on lifespan and metabolic pathways in various organisms. It …
of caloric restriction on lifespan and metabolic pathways in various organisms. It …
[HTML][HTML] Mammalian sirtuins and energy metabolism
X Li, N Kazgan - International journal of biological sciences, 2011 - ncbi.nlm.nih.gov
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-
ribosyltransferases that can extend the lifespan of several lower model organisms including …
ribosyltransferases that can extend the lifespan of several lower model organisms including …