Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function
LA Raymond, VM André, C Cepeda, CM Gladding… - Neuroscience, 2011 - Elsevier
Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …
Genetics and neuropathology of Huntington's disease
A Reiner, I Dragatsis, P Dietrich - International review of neurobiology, 2011 - Elsevier
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …
disorder that prominently affects the basal ganglia, leading to affective, cognitive, behavioral …
Huntington's disease
S Finkbeiner - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Huntington's disease (HD) is the most common inherited neurodegenerative disease and is
characterized by uncontrolled excessive motor movements and cognitive and emotional …
characterized by uncontrolled excessive motor movements and cognitive and emotional …
Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease
Huntington's disease (HD) is caused by an expanded CAG tract in the Interesting transcript
15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular stresses can trigger the …
15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular stresses can trigger the …
Differential electrophysiological changes in striatal output neurons in Huntington's disease
There is considerable evidence that alterations in striatal medium-sized spiny neurons
(MSSNs) giving rise to the direct (D1 receptor-expressing) and indirect (D2 receptor …
(MSSNs) giving rise to the direct (D1 receptor-expressing) and indirect (D2 receptor …
Strategies for regenerating striatal neurons in the adult brain by using endogenous neural stem cells
K Nakaguchi, H Masuda, N Kaneko… - Neurology Research …, 2011 - Wiley Online Library
Currently, there is no effective treatment for the marked neuronal loss caused by
neurodegenerative diseases, such as Huntington′ s disease (HD) or ischemic stroke …
neurodegenerative diseases, such as Huntington′ s disease (HD) or ischemic stroke …
Huntington's disease
JC Hedreen, RAC Roos - Neurodegeneration: the molecular …, 2011 - Wiley Online Library
This chapter reviews in depth the neuropathology of Huntington's disease, including the
Vonsattel severity classification, immunocytochemical and ultrastructural characteristics …
Vonsattel severity classification, immunocytochemical and ultrastructural characteristics …