The tumorigenicity of human embryonic and induced pluripotent stem cells
U Ben-David, N Benvenisty - Nature Reviews Cancer, 2011 - nature.com
The unique abilities of human pluripotent stem cells to self-renew and to differentiate into
cells of the three germ layers make them an invaluable tool for the future of regenerative …
cells of the three germ layers make them an invaluable tool for the future of regenerative …
The transcriptional and signalling networks of pluripotency
HH Ng, MA Surani - Nature cell biology, 2011 - nature.com
Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is
maintained by a network of transcription factors and is influenced by specific signalling …
maintained by a network of transcription factors and is influenced by specific signalling …
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine.
Typically, hESC-based applications would require their in vitro differentiation into a …
Typically, hESC-based applications would require their in vitro differentiation into a …
Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts
S Wakao, M Kitada, Y Kuroda… - Proceedings of the …, 2011 - National Acad Sciences
The stochastic and elite models have been proposed for the mechanism of induced
pluripotent stem (iPS) cell generation. In this study we report a system that supports the elite …
pluripotent stem (iPS) cell generation. In this study we report a system that supports the elite …
Small RNA‐mediated regulation of iPS cell generation
Somatic cells can be reprogrammed to an ES‐like state to create induced pluripotent stem
cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc …
cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc …
Induced pluripotent stem cells: opportunities and challenges
K Okita, S Yamanaka - … of the Royal Society B: Biological …, 2011 - royalsocietypublishing.org
Somatic cells have been reprogrammed into pluripotent stem cells by introducing a
combination of several transcription factors, such as Oct3/4, Sox2, Klf4 and c-Myc. Induced …
combination of several transcription factors, such as Oct3/4, Sox2, Klf4 and c-Myc. Induced …
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by expressing
four transcription factors: Oct4, Sox2, Klf4, and c-Myc. Here we report that enhancing RA …
four transcription factors: Oct4, Sox2, Klf4, and c-Myc. Here we report that enhancing RA …
Efficient feeder-free episomal reprogramming with small molecules
J Yu, KF Chau, MA Vodyanik, J Jiang, Y Jiang - PloS one, 2011 - journals.plos.org
Genetic reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs)
could offer replenishable cell sources for transplantation therapies. To fulfill their promises …
could offer replenishable cell sources for transplantation therapies. To fulfill their promises …
β-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
Understanding the mechanisms regulating pluripotency in embryonic and induced
pluripotent stem cells is required to ensure their safe use in clinical applications. Glycogen …
pluripotent stem cells is required to ensure their safe use in clinical applications. Glycogen …
Trophoblast stem cells
RM Roberts, SJ Fisher - Biology of reproduction, 2011 - academic.oup.com
Trophoblast stem cells (TSC) are the precursors of the differentiated cells of the placenta. In
the mouse, TSC can be derived from outgrowths of either blastocyst polar trophectoderm …
the mouse, TSC can be derived from outgrowths of either blastocyst polar trophectoderm …