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Autophagy is the major intracellular degradation system by which cytoplasmic materials are
delivered to and degraded in the lysosome. However, the purpose of autophagy is not the …

For most human complex diseases and traits, SNPs identified by genome-wide association
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …

We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

To understand the genetic heterogeneity underlying developmental delay, we compared
copy number variants (CNVs) in 15,767 children with intellectual disability and various …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …

We describe factored spectrally transformed linear mixed models (FaST-LMM), an algorithm
for genome-wide association studies (GWAS) that scales linearly with cohort size in both run …

Randomized algorithms for very large matrix problems have received a great deal of
attention in recent years. Much of this work was motivated by problems in large-scale data …

Genome-wide association studies are designed to discover SNPs that are associated with a
complex trait. Employing strict significance thresholds when testing individual SNPs avoids …

BACKGROUND Multiple laboratory tests are used to diagnose and manage patients with
diabetes mellitus. The quality of the scientific evidence supporting the use of these tests …