Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship
L Peterlin Masic - Current drug metabolism, 2011 - ingentaconnect.com
Cytochrome P450-mediated bioactivation of drugs to reactive metabolites has been reported
to be the first step in many adverse drug reactions. Metabolic activation of cyclic tertiary …
to be the first step in many adverse drug reactions. Metabolic activation of cyclic tertiary …
Drug-induced idiosyncratic hepatotoxicity: prevention strategy developed after the troglitazone case
T Ikeda - Drug metabolism and pharmacokinetics, 2011 - jstage.jst.go.jp
Troglitazone induced an idiosyncratic, hepatocellular injury-type hepatotoxicity in humans.
Statistically, double null genotype of glutathione S-transferase isoforms, GSTT1 and GSTM1 …
Statistically, double null genotype of glutathione S-transferase isoforms, GSTT1 and GSTM1 …
Profiling the reactive metabolites of xenobiotics using metabolomic technologies
F Li, J Lu, X Ma - Chemical research in toxicology, 2011 - ACS Publications
A predominant pathway of xenobiotic-induced toxicity is initiated by bioactivation.
Characterizing reactive intermediates will provide information on the structure of reactive …
Characterizing reactive intermediates will provide information on the structure of reactive …
Enhanced screening of glutathione-trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high …
X Zhu, N Kalyanaraman, R Subramanian - Analytical chemistry, 2011 - ACS Publications
A selective and sensitive approach, called extraction of product ion (XoPI) method, was
developed for the detection of l-glutathione (GSH)-trapped reactive metabolites employing …
developed for the detection of l-glutathione (GSH)-trapped reactive metabolites employing …
High‐resolution chromatography/time‐of‐flight MSE with in silico data mining is an information‐rich approach to reactive metabolite screening
JE Barbara, JM Castro‐Perez - Rapid communications in mass …, 2011 - Wiley Online Library
Electrophilic reactive metabolite screening by liquid chromatography/mass spectrometry
(LC/MS) is commonly performed during drug discovery and early‐stage drug development …
(LC/MS) is commonly performed during drug discovery and early‐stage drug development …
Overcoming the Genotoxicity of a Pyrrolidine Substituted Arylindenopyrimidine As a Potent Dual Adenosine A2A/A1 Antagonist by Minimizing Bioactivation to an …
HK Lim, J Chen, C Sensenhauser, K Cook… - Chemical research in …, 2011 - ACS Publications
2-Amino-4-phenyl-8-pyrrolidin-1-ylmethyl-indeno [1, 2-d] pyrimidin-5-one (1) is a novel and
potent selective dual A2A/A1 adenosine receptor antagonist from the arylindenopyrimidine …
potent selective dual A2A/A1 adenosine receptor antagonist from the arylindenopyrimidine …
Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species
UA Argikar, JB Mangold… - Current topics in …, 2011 - ingentaconnect.com
Metabolic activation of new chemical entities to reactive intermediates is routinely monitored
in drug discovery and development. Reactive intermediates may bind to cellular …
in drug discovery and development. Reactive intermediates may bind to cellular …
Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates
H Orhan, N PE Vermeulen - Current drug metabolism, 2011 - ingentaconnect.com
Despite several thousands of drugs are in use currently, research on new drug molecules is
continuing. Because, there are diseases still without medication, successor/better drugs …
continuing. Because, there are diseases still without medication, successor/better drugs …
D-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
JE Laine, S Auriola, M Pasanen, RO Juvonen - Toxicology in Vitro, 2011 - Elsevier
This paper describes a d-peptide isomer-based trapping assay using an LC/MS ion-trap
spectrometer with an electrospray ionization (ESI) source as the analytical tool to study …
spectrometer with an electrospray ionization (ESI) source as the analytical tool to study …
Characterization of cyanide‐trapped methylated metabonates formed during reactive drug metabolite screening in vitro
T Rousu, A Tolonen - Rapid Communications in Mass …, 2011 - Wiley Online Library
Reactive metabolites are estimated to be one of the main reasons behind unexpected drug‐
induced toxicity, by binding covalently to cell proteins or DNA. Due to their high reactivity …
induced toxicity, by binding covalently to cell proteins or DNA. Due to their high reactivity …