Owing to its ability to depict the pathologic features of multiple sclerosis (MS) in exquisite
detail, conventional magnetic resonance (MR) imaging has become an established tool in …

At the early onset of the 20 th century, several studies already reported that the gray matter
was implicated in the histopathology of multiple sclerosis (MS). However, as white matter …

Background: Although grey matter damage in multiple sclerosis is currently recognized,
determinants of grey matter volume and its relationship with disability are not yet clear …

Objective: Multiple sclerosis (MS) often results in demyelination of a network of frontal-
subcortical tracts involved in processing emotional information. We investigated the effect of …

Cognitive deficits as a result of multiple sclerosis (MS) have been documented since the
earliest clinical descriptions of MS 1; yet cognitive decline was not fully acknowledged as a …

Brain morphology and function are susceptible to various psysiological influences, including
changes in the immune system. Inflammation and autoimmunity are two principal …

Cortical subpial demyelination is frequent in multiple sclerosis (MS) and is closely
associated with disease progression and poor neurological outcome. Although cortical …

Background and objective: Predicting the long-term clinical course of multiple sclerosis (MS)
is difficult on clinical grounds. Recent studies have suggested magnetic resonance imaging …

Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and
pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship …

ABSTRACT PURPOSE To determine to what extent T1‐and T2‐regional lesion volumes
(RLVs) contribute to total and/or regional gray matter (GM) atrophy in multiple sclerosis (MS) …