Members of the monoamine oxidase family of flavoproteins catalyze the oxidation of primary
and secondary amines, polyamines, amino acids, and methylated lysine side chains in …

Epigenetic changes are critical for development and progression of cancers, including
breast cancer. Significant progress has been made in the basic understanding of how …

Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a
variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as …

A number of histone demethylases have been identified and biochemically characterized,
but the pathological roles of their dysfunction in human disease like cancer have not been …

We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key
histone modifier that participates in the maintenance of pluripotency through the regulation …

Bladder cancer is approximately three times more common in men as compared to women.
We and others have previously investigated the contribution of androgens and the androgen …

In addition to genetic disorders, epigenetic alterations have been shown to be involved in
cancer, through misregulation of histone modifications. Miswriting, misreading, and mis …

The protein lysine methyltransferase SET7 regulates DNA methyltransferase-1 (DNMT1)
activity in mammalian cells by promoting degradation of DNMT1 and thus allows epigenetic …

Covalent modifications of histones can regulate all DNA-dependent processes. In the last
few years, it has become more and more evident that histone modifications are key players …

Glioblastoma multiforme (GBM) is a particularly aggressive brain tumor and remains a
clinically devastating disease. Despite innovative therapies for the treatment of GBM, there …