In this paper we review some novel aspects related to the way adenosine A2A receptors
(A2AR) modulate the action of BDNF or its high-affinity receptors, the TrkB receptors, on …

Tau pathology is encountered in many neurodegenerative disorders known as tauopathies,
including Alzheimer's disease. Physical activity is a lifestyle factor affecting processes crucial …

J. Neurochem.(2011) 116, 747–755. Abstract It is well established that memory formation
and retention involve the coordinated flow of information from the post‐synaptic site of …

Late-phase long-term potentiation (L-LTP), a cellular model for long-term memory (LTM),
requires de novo protein synthesis. An attractive hypothesis for synapse specificity of long …

As in other diseases associated with mental retardation, dendrite morphology and synaptic
plasticity are impaired in Down's syndrome (DS). Both these features of neurons are critically …

Neurotrophic factors were originally identified based on their ability to prevent naturally
occurring cell death in the developing nervous system. Many of these proteins also promote …

A developmentally regulated loss of membrane cholesterol was reported to be sufficient and
necessary for activation of neurotrophic tyrosine kinase receptor type 2 (TrkB) in aged …

Ferulic acid (FA) is a ubiquitous phenolic acid of low toxicity, and sodium ferulate (SF) is its
sodium salt. Our previous studies have revealed that FA shows neuroprotective effect and …

The caveolin 1 gene (CAV1) is over-expressed in experimental animal models of multiple
sclerosis (MS). Increased expression of this gene has also been reported in the Alzheimer's …

MicroRNA (miRNA) 是一类内源性的介导基因沉默的小分子RNA, 在神经系统的发育,
分化及功能行使中发挥重要作用. 神经系统退行性疾病和抑郁症等多种疾病都会导致学习记忆 …