Behavioral Characterization of a Mouse Model Overexpressing DSCR1/ RCAN1
M Dierssen, G Arqué, J McDonald, N Andreu… - PloS one, 2011 - journals.plos.org
DSCR1/RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down
syndrome (DS) and postulated as a good candidate to contribute to mental disability …
syndrome (DS) and postulated as a good candidate to contribute to mental disability …
Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors
P Prasai, GC Stefos, W Becker - BMC neuroscience, 2011 - Springer
Background Treatment of neuronal PC12 cells with ATP induces depolarisation and
increases intracellular calcium levels via purinergic receptors. In many cell types, sustained …
increases intracellular calcium levels via purinergic receptors. In many cell types, sustained …
Down syndrome: A complex and interactive genetic disorder
SL Deitz, JD Blazek, JP Solzak… - Genetics and Etiology of …, 2011 - books.google.com
Down syndrome (DS) occurs in approximately 1 out of 700 live births and most commonly
results from three copies of human chromosome 21 (Hsa21)(Christianson, 2006). DS is a …
results from three copies of human chromosome 21 (Hsa21)(Christianson, 2006). DS is a …
Combinatorial gene effects on the neural progenitor pool in Down syndrome
Down syndrome (DS) arises from triplication of genes on chromosome 21 (HSA21) and is
characterized by neurological complications including cognitive dysfunction, epilepsy, and …
characterized by neurological complications including cognitive dysfunction, epilepsy, and …
[图书][B] Naming Abilities in Adults with Down Syndrome and Dementia
P Kartakis - 2011 - collectionscanada.gc.ca
Accelerated Alzheimer-like neuropathological changes have consistently been documented
in the fourth decade of life in individuals with Down syndrome (DS). Although the …
in the fourth decade of life in individuals with Down syndrome (DS). Although the …
Regulation of APP processing and Aβ production by BACE1
Y Deng - 2011 - open.library.ubc.ca
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease among elderly
people. The main symptoms of AD are memory loss and cognitive deficits. One of the …
people. The main symptoms of AD are memory loss and cognitive deficits. One of the …