As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

The vasculature of solid tumors is fundamentally different from that of normal vasculature
and offers a unique target for anti-cancer therapy. Direct vascular-targeting with Tumor …

Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-
suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of …

Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as
additional conduits for metastatic spread. The identification of growth factor receptor …

In addition to malignant neoplastic cells, cancer tissues also include immune cells,
fibroblasts, and endothelial cells, including an abundant collection of growth factors …

Sažetak Accumulating evidence shows that chronic inflammation is associated to increased
risk of cancer. An inflammatory component is present also in the microenvironment of …

Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has
been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance …

Purpose Antivascular endothelial growth factor (anti-VEGF) therapy is a promising treatment
approach for patients with recurrent glioblastoma. This single-arm phase II study evaluated …

Although our understanding of the molecular regulation of adult neovascularization has
advanced tremendously, vascular-targeted therapies for tissue ischemia remain suboptimal …