Natural killer (NK) cells are a key component of innate immunity involved not only in the
elimination of virus-infected or tumor cells but also in the regulation of the immune response …

Neuroinflammation is considered a chronic activation of the immune response in the central
nervous system (CNS) in response to different injuries. This brain immune activation results …

Human NK cells comprise two main subsets, CD56 bright and CD56 dim cells, which differ
in function, phenotype, and tissue localization. To further dissect the differentiation from …

Immunosenescence contributes to the decreased ability of the elderly to control infectious
diseases, which is also reflected in their generally poor response to new antigens and …

Influenza is a public health concern, especially for the elderly. While influenza vaccination is
efficacious in the young, it offers only limited protection in the elderly. Thus, it becomes …

The increase in the average lifespan and the consequent proportional growth of the elderly
segment of society has furthered the interest in studying ageing processes. Ageing may be …

Background The increase in life expectancy within the general population has resulted in an
increasing number of elderly adults, including patients with Down syndrome (DS), with a …

As the repertoire of αβT cell receptors (TCR) contracts with advancing age, there is an
associated age-dependent accumulation of oligoclonal T cells expressing of a variety of …

IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states,
including HIV infection, are thought to be due to increased production by homeostatic …

Aging is associated with a decline in immune function (immunosenescence) that leads to
progressive deterioration in both innate and adaptive immune functions. These changes …