Depression is highly common throughout the life course and dementia is common in late life.
Depression has been linked with dementia, and growing evidence implies that the timing of …

The brain is the key organ of stress processes. It determines what individuals will experience
as stressful, it orchestrates how individuals will cope with stressful experiences, and it …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …

The cellular basis of depressive disorders is poorly understood. Recent studies in monkeys
indicate that neurons in the lateral habenula (LHb), a nucleus that mediates communication …

Major depressive disorder (MDD) is a heterogeneous illness for which there are currently no
effective methods to objectively assess severity, endophenotypes, or response to treatment …

Depression is one of the most prevalent and life-threatening forms of mental illnesses and
the neural circuitry underlying depression remains incompletely understood. Most attention …

Particulate matter air pollution is a pervasive global risk factor implicated in the genesis of
pulmonary and cardiovascular disease. Although the effects of prolonged exposure to air …

Depression is a prevalent, highly debilitating mental disorder affecting up to 15% of the
population at least once in their lifetime, with huge costs for society. Neurobiological …

BACKGROUND: Chronic pain is clinically associated with the development of affective
disorders. However, studies in animal models of neuropathic pain are contradictory and the …