Chemopreventive and chemotherapeutic potential of curcumin in breast cancer

D Sinha, J Biswas, B Sung, BB Aggarwal… - Current drug …, 2012 - ingentaconnect.com
Breast cancer remains the leading cause of cancer death among females worldwide. It
signifies a shift from the previous decade during which the most common cause of cancer …

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

SU Gandhy, KH Kim, L Larsen, RJ Rosengren, S Safe - BMC cancer, 2012 - Springer
Background Curcumin inhibits growth of several cancer cell lines, and studies in this
laboratory in bladder and pancreatic cancer cells show that curcumin downregulates …

Synthesis and evaluation of curcumin-related compounds for anticancer activity

X Wei, ZY Du, X Zheng, XX Cui, AH Conney… - European journal of …, 2012 - Elsevier
Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer
activity toward cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon …

Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells

X Wei, ZY Du, XX Cui, M Verano, RQ Mo… - Oncology …, 2012 - spandidos-publications.com
Curcumin is a non-nutritive yellow pigment found in the spice turmeric, which is derived from
the rhizome of the plant Curcuma longa Linn. Six cyclohexanone analogues of curcumin (A1 …

[HTML][HTML] RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells

B Yadav, S Taurin, L Larsen… - … journal of oncology, 2012 - spandidos-publications.com
There is a need for the development of new, safe and efficacious drug therapies for the
treatment of estrogen receptor (ER)-negative breast cancers. RL71 is a second-generation …

RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER‑negative breast cancer models

B Yadav, S Taurin, L Larsen… - … journal of oncology, 2012 - spandidos-publications.com
There is a need for the development of new safe and efficacious drug therapies for the
treatment of estrogen receptor (ER)‑negative breast cancers. 1-Methyl-3, 5-bis [(E)-4-pyridyl) …

Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells

E Leung, GW Rewcastle, WR Joseph… - Investigational New …, 2012 - Springer
Breast cancer is commonly treated with anti-estrogens or aromatase inhibitors, but resistant
disease eventually develops and new therapies for such resistance are of great interest. We …

[HTML][HTML] Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

S Safe, RJ Rosengren, L Larsen, KH Kim, SU Gandhy - 2012 - oa.las.ac.cn
Background Curcumin inhibits growth of several cancer cell lines, and studies in this
laboratory in bladder and pancreatic cancer cells show that curcumin downregulates …

Systhesis, Characterization and Spectroscopic Properties of (2E, 6E)-2, 6-Bis (2, 3, 4-tri-methoxy-benzylidene) cyclohexanone

XC Wei, ZL Liu, K Zhang, ZY Du… - Advanced Materials …, 2012 - Trans Tech Publ
In this paper,(2E, 6E)-2, 6-Bis (2, 3, 4-tri-methoxy-benzylidene) cyclohexanone (omitted as
tmbcho)(1) was obtained by the reaction of acetic acid, tetrahydrofuran, cyclohexanone and …