Alpha-synuclein: from secretion to dysfunction and death
O Marques, TF Outeiro - Cell death & disease, 2012 - nature.com
The aggregation, deposition, and dysfunction of alpha-synuclein (aSyn) are common events
in neurodegenerative disorders known as synucleinopathies. These include Parkinson's …
in neurodegenerative disorders known as synucleinopathies. These include Parkinson's …
The neuropathology, pathophysiology and genetics of multiple system atrophy
Z Ahmed, YT Asi, A Sailer, AJ Lees… - Neuropathology and …, 2012 - Wiley Online Library
Z. Ahmed, YT Asi, A. Sailer, AJ Lees, H. Houlden, T. Revesz and JL Holton (2012)
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
Parkinson's disease (PD) is characterized by widespread alpha-synuclein pathology and
neuronal loss, primarily of the nigrostriatal dopaminergic neurons. Inflammation has been …
neuronal loss, primarily of the nigrostriatal dopaminergic neurons. Inflammation has been …
A Spirulina-Enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease
MM Pabon, JN Jernberg, J Morganti, J Contreras… - 2012 - journals.plos.org
Inflammation in the brain plays a major role in neurodegenerative diseases. In particular,
microglial cell activation is believed to be associated with the pathogenesis of …
microglial cell activation is believed to be associated with the pathogenesis of …
Molecular insights into Parkinson's disease
JC Rochet, BA Hay, M Guo - … in molecular biology and translational science, 2012 - Elsevier
Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or
autosomal-recessive forms of Parkinson's disease (PD), the second most common …
autosomal-recessive forms of Parkinson's disease (PD), the second most common …
Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
P Barkholt, V Sanchez-Guajardo, D Kirik… - Neuroscience, 2012 - Elsevier
We have previously shown that persistent α-synuclein overexpression in ventral midbrain of
marmoset leads to a distinctive neurodegenerative process and motor defects. The …
marmoset leads to a distinctive neurodegenerative process and motor defects. The …
Genetically engineered mouse models of Parkinson's disease
DM Crabtree, J Zhang - Brain research bulletin, 2012 - Elsevier
Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
affecting more than 1% of the population over age 60. The most common feature of PD is a …
affecting more than 1% of the population over age 60. The most common feature of PD is a …
Lack of Association Between CX3CR1 V249I and T280M Polymorphisms and Risk of Parkinson's Disease in a Greek Population
K Kalinderi, S Bostantjopoulou, Z Katsarou… - Genetic Testing and …, 2012 - liebertpub.com
Mechanisms that mediate inflammatory responses may be crucial in Parkinson's disease
(PD) pathogenesis. In the brain, the chemokine receptor CX3CR1 is exclusively expressed …
(PD) pathogenesis. In the brain, the chemokine receptor CX3CR1 is exclusively expressed …
The role of microglia–lymphocyte interaction in PD neuropathology
AR Carta - Basal Ganglia, 2012 - Elsevier
Neuroinflammation is a major pathological component of Parkinson's disease. Chronic
microglial response dominates the histopathology of parkinsonian substantia nigra. In …
microglial response dominates the histopathology of parkinsonian substantia nigra. In …
and Kathleen A. Maguire-Zeiss
TR Mhyre, JT Boyd, RW Hamill - Protein Aggregation and …, 2012 - books.google.com
Parkinson's disease (PD) is the most common age-related motoric neurodegenerative
disease initially described in the 1800's by James Parkinson as the 'Shaking Palsy'. Loss of …
disease initially described in the 1800's by James Parkinson as the 'Shaking Palsy'. Loss of …