Ankylosing spondylitis (AS), psoriasis and inflammatory bowel disease (IBD) often coexist in
the same patient and in their families. In AS, genes within the MHC region, in particular HLA …

Driven by advances in molecular genetic technologies and statistical analysis
methodologies, there have been huge strides taken in dissecting the complex genetic basis …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …

Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically,
pathologically, and therapeutically connected, but little is known about their shared genetic …

Psoriasis is a complex disease with an expanding definition of its pathological features. We
sought to expand/refine the psoriasis transcriptome using 85 paired lesional and non …

Objective To identify susceptibility loci for Behçet's disease (BD) and elucidate their
functional role. Methods A genome‐wide association study (GWAS) and functional studies …

Prostate cancer risk–associated variants have been reported in populations of European
descent, African-Americans and Japanese using genome-wide association studies (GWAS) …

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-
wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 …

Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for
example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance …

Psoriasis was until recently regarded as a T-cell-driven disease with presumed (auto)
immune mechanisms as its primary cause. This view was supported by clinical data and …