DNA is a polymeric macromolecule whose biological activities depend on location as well
as binding to associated molecules. Inside the cell, DNA is the source of genetic information …

RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

Tumors and the immune system are intertwined in a competition where tilting the fine
balance between tumor‐specific immunity and tolerance can ultimately decide the fate of the …

Despite recent advances in targeted therapies, patients with pancreatic adenocarcinoma
continue to have poor survival highlighting the urgency to identify novel therapeutic targets …

Clinical manifestations of most rheumatic diseases have changed over the past few
decades, largely due to advances in therapies targeting autoimmune and (auto) …

Objective. To examine the role of ethnicity and the use of anti-malarials (protective) on lupus
renal disease. Methods. A nested case–control study (1: 2 proportion, n= 265 and 530) …

Background Inflammatory bowel disease (IBD) is a complex disorder involving pathogen
infection, host immune response, and altered enterocyte physiology. Incidences of IBD are …

Sir, Hydroxychloroquine (HCQ) is a disease-modifying antirheumatic drug used in the
treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 1–3 SLE …

Arsenal of pattern-recognition receptors alongside antibody production machinery make B
cells vulnerable to autoimmune response if an autoantigen elicits both pathways in a self …

Chloroquine (CQ) and other quinoline-containing antimalarials are important drugs with
many therapeutic benefits as well as adverse effects. However, the molecular targets …