[HTML][HTML] Respiratory and olfactory cytotoxicity of inhaled 2, 3-pentanedione in Sprague-Dawley rats

AF Hubbs, AM Cumpston, WT Goldsmith… - The American journal of …, 2012 - Elsevier
Flavorings-related lung disease is a potentially disabling disease of food industry workers
associated with exposure to the α-diketone butter flavoring, diacetyl (2, 3-butanedione). To …

Methylglyoxal inhibition of cytosolic ascorbate peroxidase from Nicotiana tabacum

MA Hoque, M Uraji, A Torii, MNA Banu… - … of Biochemical and …, 2012 - Wiley Online Library
Methylglyoxal (MG) is one of the aldehydes accumulated in plants under environmental
stress. Cytosolic ascorbate peroxidase (cAPX) plays a key role in the protection of cells from …

[HTML][HTML] Long term running biphasically improves methylglyoxal-related metabolism, redox homeostasis and neurotrophic support within adult mouse brain cortex

S Falone, A D'Alessandro, A Mirabilio, G Petruccelli… - PloS one, 2012 - journals.plos.org
Oxidative stress and neurotrophic support decline seem to be crucially involved in brain
aging. Emerging evidences indicate the pro-oxidant methylglyoxal (MG) as a key player in …

Dual Effect of Methylglyoxal on the Intracellular Ca2+ Signaling and Neurite Outgrowth in Mouse Sensory Neurons

BM Radu, DI Dumitrescu, CC Mustaciosu… - Cellular and molecular …, 2012 - Springer
The formation of advanced glycation end products is one of the major factors involved in
diabetic neuropathy, aging, and neurodegenerative diseases. Reactive carbonyl …

[HTML][HTML] Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus

S Falone, A D'Alessandro, A Mirabilio, M Cacchio… - PLoS …, 2012 - journals.plos.org
Despite the active research in this field, molecular mechanisms underlying exercise-induced
beneficial effects on brain physiology and functions are still matter of debate, especially with …

[HTML][HTML] Cytoplasmic and nuclear anti-apoptotic roles of αB-crystallin in retinal pigment epithelial cells

WJ Jeong, JH Rho, YG Yoon, SH Yoo, NY Jeong… - 2012 - journals.plos.org
In addition to its well-characterized role in the lens, αB-crystallin performs other functions.
Methylglyoxal (MGO) can alter the function of the basement membrane of retinal pigment …

Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells

F Hansen, DF de Souza, SL Silveira, AL Hoefel… - Metabolic Brain …, 2012 - Springer
Methylglyoxal is a dicarbonyl compound that is physiologically produced by enzymatic and
non-enzymatic reactions. It can lead to cytotoxicity, which is mainly related to Advanced …

[图书][B] Aging: Drugs to eliminate methylglyoxal, a reactive glucose metabolite, and advanced glycation endproducts

I Dhar, K Desai - 2012 - researchgate.net
The aging process not only affects the whole body, but also affects individual cells. While the
age-related changes in the body are popularly recognized as wrinkling of the skin, indicating …