Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and
is associated with decreased or absent expression of the transcription factor NK2 homeobox …

Abstract Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-
1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it …

Hox genes encode transcription factors controlling complex developmental processes in
various organs. Little is known, however, about how HOX proteins control cell fate. Herein …

Premature infants frequently develop bronchopulmonary dysplasia (BPD). Lung immaturity
and impaired epithelial differentiation contribute together with invasive oxygen treatment to …

Mucous cell metaplasia (MCM) and neutrophil-predominant airway inflammation are
pathological features of chronic inflammatory airway diseases. A signature feature of MCM is …

Allergic asthma is a chronic disease of the lung characterized by underlying Th2-and IgE-
mediated inflammation, structural alterations of the bronchial wall, and airway …

Asthma is a chronic inflammatory disorder of the airways that leads to acute episodes of
wheezing; exacerbations; and for a small part of the population, fatal or near-fatal …

While asthma is an inflammatory disorder of the conducting airways with strong allergic
overtones, the variable and often low clinical response to selective treatments that target the …

Major scientific advances in prenatal and neonatal physiology have provided the basis for
improved outcomes for preterm and other infants with disorders causing respiratory failure …