Evolution of SR protein and hnRNP splicing regulatory factors
A Busch, KJ Hertel - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
The splicing of pre‐mRNAs is an essential step of gene expression in eukaryotes. Introns
are removed from split genes through the activities of the spliceosome, a large ribonuclear …
are removed from split genes through the activities of the spliceosome, a large ribonuclear …
Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL
M Pirruccello, P De Camilli - Trends in biochemical sciences, 2012 - cell.com
The precise regulation of phosphoinositide lipids in cellular membranes is crucial for cellular
survival and function. Inositol 5-phosphatases have been implicated in a variety of disorders …
survival and function. Inositol 5-phosphatases have been implicated in a variety of disorders …
The evolutionary landscape of alternative splicing in vertebrate species
How species with similar repertoires of protein-coding genes differ so markedly at the
phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate …
phenotypic level is poorly understood. By comparing organ transcriptomes from vertebrate …
Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy
BACKGROUND: Dilated cardiomyopathy (DCM) is a leading cause of heart failure and
death. The etiology of DCM is genetically heterogeneous. OBJECTIVES: We sought to …
death. The etiology of DCM is genetically heterogeneous. OBJECTIVES: We sought to …
Effects of genotype and child abuse on DNA methylation and gene expression at the serotonin transporter
M Vijayendran, SRH Beach, JM Plume… - Frontiers in …, 2012 - frontiersin.org
Altered regulation of the serotonin transporter (SLC6A4) is hypothesized to be a key event in
many forms of neuropsychiatric illness, yet our understanding of the molecular mechanisms …
many forms of neuropsychiatric illness, yet our understanding of the molecular mechanisms …
Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy
Although both physiological hypertrophy (PHH) and pathological hypertrophy (PAH) of the
heart have similar morphological appearances, only PAH leads to fatal heart failure. In the …
heart have similar morphological appearances, only PAH leads to fatal heart failure. In the …
Deciphering the plant splicing code: experimental and computational approaches for predicting alternative splicing and splicing regulatory elements
Extensive alternative splicing (AS) of precursor mRNAs (pre-mRNAs) in multicellular
eukaryotes increases the protein-coding capacity of a genome and allows novel ways to …
eukaryotes increases the protein-coding capacity of a genome and allows novel ways to …
Comparative proteomics reveals a significant bias toward alternative protein isoforms with conserved structure and function
Advances in high-throughput mass spectrometry are making proteomics an increasingly
important tool in genome annotation projects. Peptides detected in mass spectrometry …
important tool in genome annotation projects. Peptides detected in mass spectrometry …
MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics
R Kryger, L Fan, PA Wilce, V Jaquet - Alcohol, 2012 - Elsevier
Chronic alcohol intake induces neurochemical adaptative changes in the brain
characterised by altered gene expression. A role for non-coding RNAs in alcoholism is …
characterised by altered gene expression. A role for non-coding RNAs in alcoholism is …
Alternative splicing: a potential source of functional innovation in the eukaryotic genome
L Chen, JM Tovar-Corona… - International journal of …, 2012 - Wiley Online Library
Alternative splicing (AS) is a common posttranscriptional process in eukaryotic organisms,
by which multiple distinct functional transcripts are produced from a single gene. The …
by which multiple distinct functional transcripts are produced from a single gene. The …