Brain meets body: the blood-brain barrier as an endocrine interface
WA Banks - Endocrinology, 2012 - academic.oup.com
The blood-brain barrier (BBB) separates the central nervous system (CNS) from the
peripheral tissues. However, this does not prevent hormones from entering the brain, but …
peripheral tissues. However, this does not prevent hormones from entering the brain, but …
[HTML][HTML] Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding …
SN Roed, A Orgaard, R Jorgensen… - Frontiers in …, 2012 - frontiersin.org
The superfamily of the seven transmembrane G-protein-coupled receptors (7TM/GPCRs) is
the largest family of membrane-associated receptors. GPCRs are involved in the …
the largest family of membrane-associated receptors. GPCRs are involved in the …
[HTML][HTML] Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretion
We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta
(ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 …
(ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 …
Ligand binding and activation of the secretin receptor, a prototypic family BG protein‐coupled receptor
LJ Miller, M Dong, KG Harikumar - British journal of …, 2012 - Wiley Online Library
The secretin receptor is a prototypic member of family BG protein‐coupled receptors that
binds and responds to a linear 27‐residue peptide natural ligand. The carboxyl‐terminal …
binds and responds to a linear 27‐residue peptide natural ligand. The carboxyl‐terminal …
[HTML][HTML] The VPAC1 receptor: structure and function of a class B GPCR prototype
A Couvineau, E Ceraudo, YV Tan… - Frontiers in …, 2012 - frontiersin.org
The class BG protein-coupled receptors (GPCRs) represents a small sub-family
encompassing 15 members, and are very promising targets for the development of drugs to …
encompassing 15 members, and are very promising targets for the development of drugs to …
Characterization of chicken secretin (SCT) and secretin receptor (SCTR) genes: a novel secretin-like peptide (SCT-LP) and secretin encoded in a single gene
Y Wang, G Huang, J Li, F Meng, X He… - Molecular and cellular …, 2012 - Elsevier
Secretin and the secretin receptor have been reported to play an important role in regulating
pancreatic water and bicarbonate secretion in mammals; however, little is known about their …
pancreatic water and bicarbonate secretion in mammals; however, little is known about their …
[HTML][HTML] Intranasal application of secretin, similarly to intracerebroventricular administration, influences the motor behavior of mice probably through specific receptors
A Heinzlmann, G Kiss, ZE Tóth, R Dochnal… - Journal of Molecular …, 2012 - Springer
Secretin and its receptors show wide distribution in the central nervous system. It was
demonstrated previously that intravenous (iv) and intracerebroventricular (icv) application of …
demonstrated previously that intravenous (iv) and intracerebroventricular (icv) application of …
Parathyroid Hormone and Calcium Homeostasis
JT Potts, TJ Gardella - Pediatric Bone, 2012 - Elsevier
Publisher Summary Parathyroid hormone (PTH) and PTH-related peptide (PTHrP), along
with other calciotropic hormones, play critical roles in calcium homeostasis and bone …
with other calciotropic hormones, play critical roles in calcium homeostasis and bone …
Generation of new GPCR-antibodies for target validation in tumor diagnosis and therapy
Q Schefer - 2012 - refubium.fu-berlin.de
Early diagnosis and detection of small tumors and metastases are crucial for successful
cancer therapy. A very promising approach for sensitive tumor imaging and therapy is the …
cancer therapy. A very promising approach for sensitive tumor imaging and therapy is the …