Carbohydrates play a central role in a wide range of biological processes. As with nucleic
acids and proteins, modifications of specific sites within the glycan chain can modulate a …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

BackgroundUnderstanding individual differences in susceptibility to antidepressant therapy
side-effects is essential to optimize the treatment of depression. MethodWe performed …

Affecting about 1 in 12 Americans annually, depression is a leading cause of the global
disease burden. While a range of effective antidepressants are now available, failure and …

The successful application of pharmacogenetics in routine clinical practice is still a long way
from becoming a reality. In order to favor the transfer of pharmacogenetic results to clinical …

We investigated the association of dopamine receptor D1 gene (DRD1) rs4532
polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed …

Antipsychotic drugs are limited in their efficacy by the relatively poor response of negative
and cognitive symptoms of schizophrenia as well as by the substantial variability in …

Slc26 anion transporters play crucial roles in transepithelial Cl− absorption and HCO3−
secretion; Slc26 protein mutations lead to several diseases. Slc26a9 functions as a Cl …

Objective: To evaluate a common genetic variant, sulfotransferase 4A1 haplotype 1
(SULT4A1-1), as a predictor of hospitalization events due to the exacerbation of …

Recent advances in genomic technologies have enabled the identification of thousands of
genetic variations that are associated with hundreds of complex human diseases or traits in …