The notion of the “biological individual” is crucial to studies of genetics, immunology,
evolution, development, anatomy, and physiology. Each of these biological subdisciplines …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

An academic scientist's professional success depends on publishing. Publishing norms
emphasize novel, positive results. As such, disciplinary incentives encourage design …

The resolution of genome-wide association studies (GWAS) is limited by the linkage
disequilibrium (LD) structure of the population being studied. Selecting the most likely …

Many genomes have been sequenced to high-quality draft status using Sanger capillary
electrophoresis and/or newer short-read sequence data and whole genome assembly …

Abstract The Allen Brain Atlas (http://www. brain-map. org) provides a unique online public
resource integrating extensive gene expression data, connectivity data and …

Humans are essentially sterile during gestation, but during and after birth, every body
surface, including the skin, mouth, and gut, becomes host to an enormous variety of …

The falling cost of genome sequencing is having a marked impact on the research
community with respect to which genomes are sequenced and how and where they are …

Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …