The human leukocyte antigen (HLA) genes are the most polymorphic in the human genome
and are critical in regulating specific immunity, hence their historical discovery as “immune …

The major histocompatibility complex (MHC) region on the short arm of chromosome 6
harbors the largest number of replicated associations across the human genome for a wide …

It is 14 years since the IMGT/HLA database was first released, providing the HLA community
with a searchable repository of highly curated HLA sequences. The HLA complex is located …

Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic
and environmental factors. On the basis of data from a genome-wide association study …

In plants, the genomic clustering of non-homologous genes for the biosynthesis of chemical
defense compounds is an emerging theme. Gene clustering is also observed for …

Turner Syndrome (TS) is a common genetic disorder, affecting female individuals, resulting
from the partial or complete absence of one sex chromosome, and occurring in …

MHC I–associated peptides (MIPs) play an essential role in normal homeostasis and diverse
pathologic conditions. MIPs derive mainly from defective ribosomal products (DRiPs), a …

There is genetic evidence that schizophrenia is a polygenic disorder with a large number of
loci of small effect on disease susceptibility. Genome-wide association studies (GWASs) of …

Vitiligo is a depigmenting disorder of the skin that is characterized by the loss of functional
melanocytes from the lesional sites. Although the exact etiology is not understood …

Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease.
Complete deficiency of complement component C4 confers strong genetic risk for SLE …