Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis

JA Fielhaber, SF Carroll, AB Dydensborg… - The Journal of …, 2012 - journals.aai.org
Acute lung injury during bacterial infection is associated with neutrophilic inflammation,
epithelial cell apoptosis, and disruption of the alveolar-capillary barrier. TLR4 is required for …

Paradoxical effects of rapamycin on experimental house dust mite-induced asthma

K Fredriksson, JA Fielhaber, JK Lam, X Yao, KS Meyer… - PloS one, 2012 - journals.plos.org
The mammalian target of rapamycin (mTOR) modulates immune responses and cellular
proliferation. The objective of this study was to assess whether inhibition of mTOR with …

Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin

JA Fielhaber, J Tan, KB Joung, O Attias… - Journal of Biological …, 2012 - ASBMB
Under conditions of reduced mitogen or nutritional substrate levels, the serine/threonine
kinase target of rapamycin can augment the nuclear content of distinct transcription factors …

Regulatory role of the mechanistic target of Rapamycin (mTOR) on the expression of osmotic stress response genes in mammalian cells

MCO Campos - 2012 - dialnet.unirioja.es
Las respuestas adaptativas frente al estrés permiten a las células mantener su crecimiento
así como su potencial proliferativo. Aunque se ha establecido que el crecimiento y la …

[PDF][PDF] Paradoxical Effects of Rapamycin on Experimental House Dust Mite-Induced

K Fredriksson, JA Fielhaber, JK Lam, X Yao, KS Meyer - 2012 - Citeseer
The mammalian target of rapamycin (mTOR) modulates immune responses and cellular
proliferation. The objective of this study was to assess whether inhibition of mTOR with …

[引用][C] Inhibition of Mammalian Target of

R Augments - 2012