The disturbed blood–brain barrier in human glioblastoma

H Wolburg, S Noell, P Fallier-Becker, AF Mack… - Molecular aspects of …, 2012 - Elsevier
The aim of this article is to describe alterations of the blood–brain barrier (BBB) in gliomas.
The main clinical problem of human gliomas is the edematous swelling and the dramatic …

Nanotechnologies: a strategy to overcome blood-brain barrier

G De Rosa, G Salzano, M Caraglia… - Current drug …, 2012 - ingentaconnect.com
The possibility to treat central nervous system (CNS) disorders is strongly limited by the poor
access of many therapeutic agent to the target tissues. This is mainly due to the presence of …

Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice

M Liu, DG Kuhel, L Shen, DY Hui… - American Journal of …, 2012 - journals.physiology.org
Apolipoprotein E (apoE) is a 34-kDa glycoprotein that is important in lipoprotein metabolism
both peripherally and centrally. Because it is primarily produced in the liver, apoE observed …

Dynamics of expression patterns of AQP4, dystroglycan, agrin and matrix metalloproteinases in human glioblastoma

S Noell, K Wolburg-Buchholz, AF Mack, R Ritz… - Cell and tissue …, 2012 - Springer
In human glioblastoma, the blood–brain barrier (BBB) is disturbed. According to our concept,
the glio-vascular relationships and thus the control of the BBB are essentially dependent on …

[HTML][HTML] Effects of amyloid beta peptide on neurovascular cells

S Askarova, A Tsoy, T Shalakhmetova… - Central Asian Journal …, 2012 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a chronic neurodegenerative disorder, which is characterized by
the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the …

[图书][B] Preparation and characterization of electrospun poly (D, L-Lactide-co-Glycolide) scaffolds for vascular tissue engineering and the advancement of an in vitro …

DC Patel - 2012 - search.proquest.com
Developing an in vitroBlood Brain Barrier model that will replicate the physiological,
anatomical, and functional characteristics of the native BBB has gained significant attention …

Blood-Brain Barrier during cerebral maturation: impact of neuro-inflammation on the regulation of drug-efflux/influx transporters

R Harati - 2012 - theses.hal.science
One major reason of CNS pharmacotherapy's impediment is the existence of “barriers”
between blood and CNS, especially the Blood-Brain Barrier (BBB), a neurovascular …

Characterizing the expression profile of angiogenic proteins after acute spinal cord injury

TLM Ng - 2012 - open.library.ubc.ca
Spinal cord injuries (SCI) are one of the most physically and psychologically devastating
injuries one can survive. Despite decades of intense research effort, robust therapeutic …