The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial disease.
Recently, a readily transferable antibiotic resistance factor called the New Delhi metallo-β …

In an effort to biochemically characterize metallo-β-lactamase NDM-1, we cloned,
overexpressed, purified, and characterized several maltose binding protein (MBP)–NDM-1 …

Staphylococcus aureus clonal complex CC30 has caused infectious epidemics for more
than 60 years, and, therefore, provides a model system to evaluate how evolution has …

Enolase is a conserved cytoplasmic metalloenzyme existing universally in both eukaryotic
and prokaryotic cells. The enzyme can also locate on the cell surface and bind to …

New Delhi metallo-β-lactamase 1 (NDM-1) is a key enzyme that the pathogen Klebsiella
pneumonia uses to hydrolyze almost all β-lactam antibiotics. It is currently unclear why NDM …

New Delhi metallo-β-lactamase (NDM-1) has created a medical storm ever since it was first
reported; as it is active on virtually all clinically used β-lactam antibiotics. NDM-1 rampancy …

Background Genes conferring antibiotic resistance to groups of bacterial pathogens are
cause for considerable concern, as many once-reliable antibiotics continue to see a …

Medical tourism entails two activities known to spread infections—travel and hospital
procedures. Combined, and absent the necessary safeguards, these activities have the …

Gram-negative bacilli, Enterobacteriaceae and Non-fermentors with resistance to
carbapenems and metallo beta-lactams are the major cause of concern in clinical problems …

The increasing prevalence of acquired carbapenemases in Gram-negative bacteria is one of
the biggest problems in the prevention and therapy of infectious diseases. NDM (New Delhi …