Objectives: The purpose of this study was to estimate the effect of long-term exposure to
lower plasma low-density lipoprotein cholesterol (LDL-C) on the risk of coronary heart …

Cardiovascular disease encompasses a range of conditions extending from myocardial
infarction to congenital heart disease, most of which are heritable. Enormous effort has been …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

Population structure causes genome-wide linkage disequilibrium between unlinked loci,
leading to statistical confounding in genome-wide association studies. Mixed models have …

The metabolic syndrome, a common disorder including glucose intolerance and
dyslipidemia, poses a major public health issue. Patients with high blood lipids, such as …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom∼ 50,000 SNP genotyping array (the ITMAT-Broad-CARe …

The past decade has seen a rapid development and increasing recognition of ANGPTL4
(angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic …

Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for
the development and function of the human brain. They can be obtained directly from food …

Background—Genome-wide association (GWA) studies have identified several susceptibility
loci for metabolic syndrome (MetS) component traits, but have had variable success in …

Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences
on metabolic phenotypes is key to a systems-wide understanding of their interactions with …