Importance of quantification for the analysis of PET data in oncology: review of current methods and trends for the future

G Tomasi, F Turkheimer, E Aboagye - Molecular Imaging and Biology, 2012 - Springer
In oncology, positron emission tomography (PET) is an important tool for tumour diagnosis
and staging, assessment of response to treatment and evaluation of the pharmacokinetic …

[HTML][HTML] Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors

AL Van De Ven, M Wu, J Lowengrub, SR McDougall… - AIP advances, 2012 - pubs.aip.org
Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics
delivery to tumors | AIP Advances | AIP Publishing Skip to Main Content Umbrella Alt Text …

[HTML][HTML] Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis

X Sun, L Zhang, H Tan, J Bao, C Strouthos, X Zhou - BMC bioinformatics, 2012 - Springer
Background The epidermal growth factor receptor (EGFR) signaling pathway and
angiogenesis in brain cancer act as an engine for tumor initiation, expansion and response …

A hybrid discrete-continuum mathematical model of pattern prediction in the developing retinal vasculature

SR McDougall, MG Watson, AH Devlin… - Bulletin of mathematical …, 2012 - Springer
Pathological angiogenesis has been extensively explored by the mathematical modelling
community over the past few decades, specifically in the contexts of tumour-induced …

Continuation along bifurcation branches for a tumor model with a necrotic core

W Hao, JD Hauenstein, B Hu, Y Liu… - Journal of Scientific …, 2012 - Springer
We consider a free boundary problem for a system of partial differential equations, which
arises in a model of tumor growth with a necrotic core. For any positive number R and 0< ρ< …

A hybrid discrete-continuum model of tumour induced angiogenesis

ARA Anderson, MAJ Chaplain, S McDougall - Modeling tumor vasculature …, 2012 - Springer
Angiogenesis, the formation of new blood vessels, is a crucial step in solid tumour
development, as it links the relatively harmless avascular and the potentially fatal vascular …

Optimisation of cancer drug treatments using cell population dynamics

F Billy, J Clairambault, O Fercoq - Mathematical Methods and Models in …, 2012 - Springer
Cancer is primarily a disease of the physiological control on cell population proliferation.
Tissue proliferation relies on the cell division cycle: one cell becomes two after a sequence …

On the importance of the submicrovascular network in a computational model of tumour growth

AC Lesart, B van Der Sanden, L Hamard, F Estève… - Microvascular …, 2012 - Elsevier
A computational model is potentially a powerful tool to apprehend complex phenomena like
solid tumour growth and to predict the outcome of therapies. To that end, the confrontation of …

Optimization of vascular-targeting drugs in a computational model of tumor growth

J Gevertz - Physical Review E—Statistical, Nonlinear, and Soft …, 2012 - APS
A biophysical tool is introduced that seeks to provide a theoretical basis for helping drug
design teams assess the most promising drug targets and design optimal treatment …

Fractional Gaussian noise-induced evolution and transition in anti-tumor model

FG Li, BQ Ai - The European Physical Journal B, 2012 - Springer
Noise induced evolution and transition in an anti-tumor model under immune surveillance
are investigated in the presence of additive fractional Gaussian noises. Unlike white …