Functional differences between direct and indirect striatal output pathways in Huntington's disease
L Galvan, VM André, EA Wang… - Journal of …, 2012 - content.iospress.com
There is morphological evidence for differential alterations in striatal medium-sized spiny
neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's …
neurons (MSNs) giving rise to the direct and indirect output pathways in Huntington's …
The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice
A Reiner, DC Lafferty, HB Wang, N Del Mar… - Neurobiology of …, 2012 - Elsevier
Excitotoxic injury to striatum by dysfunctional cortical input or aberrant glutamate uptake may
contribute to Huntington's disease (HD) pathogenesis. Since corticostriatal terminals …
contribute to Huntington's disease (HD) pathogenesis. Since corticostriatal terminals …
Abnormal burst patterns of single neurons recorded in the substantia nigra reticulata of behaving 140 CAG Huntington's disease mice
A Murphy-Nakhnikian, JL Dorner, BI Fischer… - Neuroscience …, 2012 - Elsevier
Huntington's disease (HD) is an inherited neurodegenerative disorder that causes
neurological pathology in the basal ganglia and related circuitry. A key site of HD pathology …
neurological pathology in the basal ganglia and related circuitry. A key site of HD pathology …
The protein SS18L1 is a potent suppressor of polyQ-mediated huntingtin aggregation and toxicity
A Möller - 2012 - edoc.hu-berlin.de
Huntington's Disease (HD) is a neurodegenerative disease, which is characterised by motor,
cognitive and psychiatric disturbances. The abnormal extension of an N-terminal polyQ tract …
cognitive and psychiatric disturbances. The abnormal extension of an N-terminal polyQ tract …
Investigating the mechanism of promoter-specific N-terminal mutant huntingtin-mediated transcriptional dysregulation
M Hogel - 2012 - dalspace.library.dal.ca
Huntington's disease (HD) is a neurodegenerative disorder caused by the inheritance of one
mutant copy of the huntingtin gene. Mutant huntingtin protein (mHtt) contains an expanded …
mutant copy of the huntingtin gene. Mutant huntingtin protein (mHtt) contains an expanded …
[引用][C] CHARACTERIZING THE FUNCTION OF HUNTINGTIN IN THE CELL STRESS RESPONSE AS A TARGET FOR DRUG DISCOVERY IN HUNTINGTON'S …
LN Munsie - 2012