How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …

Objectives: Evidence suggests that childhood maltreatment may negatively affect not only
the lifetime risk of depression but also clinically relevant measures of depression, such as …

BACKGROUND: Research suggests that adverse experiences in childhood affect the
development of cardiovascular disease (CVD), and immune and inflammation dysregulation …

Objectives.—Migraine is a risk factor for stroke in young women. Biomarker studies implicate
endothelial activation as a possible mechanism. Emerging relationships of childhood …

Parenting quality and children's mental health: biological m... : Current Opinion in Psychiatry
Parenting quality and children's mental health: biological mechanisms and psychological …

Objective Early-life stress may influence health later in life. We examined morbidity and
mortality from cardiovascular disease over 60 years in individuals separated temporarily …

OBJECTIVE: Maltreatment in childhood has been related to enduring changes in the
immune system of adults, such as increased cell-mediated immune response. PURPOSE …

Objectives Childhood adversities may be important determinants of later illnesses and poor
health behaviour. However, large-scale prospective studies on the associations between …

The systems theory of autistogenesis accounts for genetic and environmental predisposing
factors for pervasive developmental disorders. During development, regions of the brain …